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Abstract #5347

Dyslexia therapy customization based on dorsal-ventral pathway representation

Sunita Gudwani1, Senthil Kumaran1, Rajesh Sagar2, SN Dwivedi3, and Naranamangalam R Jagannathan1

1Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, 2Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India, 3Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India

Reading necessitates skill mastering of phonological (sound to letter), orthographic (knowledge of letter identities, position), and semantic (words meaning) processing requiring optimal interface of ventral-dorsal routes. Dyslexia, a developmental reading disorder, is an umbrella term with heterogeneity of behavioral deficits constrains the management efficiency. Persistent deficits lead to emotional, academic, social consequences necessitating evidence-based interventions. The study was planned on neurobiological-model to customize the therapeutic management. Dorsal pathway (BOLD activation) reorganization associated with improvement in reading rate, accuracy, spelling and writing flow suggest neurobiological normalization in dyslexics observed post-remediation on comparing therapy group with non-therapy and age-matched typical readers.

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