Reading necessitates skill mastering of phonological (sound to letter), orthographic (knowledge of letter identities, position), and semantic (words meaning) processing requiring optimal interface of ventral-dorsal routes. Dyslexia, a developmental reading disorder, is an umbrella term with heterogeneity of behavioral deficits constrains the management efficiency. Persistent deficits lead to emotional, academic, social consequences necessitating evidence-based interventions. The study was planned on neurobiological-model to customize the therapeutic management. Dorsal pathway (BOLD activation) reorganization associated with improvement in reading rate, accuracy, spelling and writing flow suggest neurobiological normalization in dyslexics observed post-remediation on comparing therapy group with non-therapy and age-matched typical readers.