Despite the fact that alcohol have impact on human brain function, the mechanism is not yet well understood. In order to detect the changes of blood perfusion information based on PCASL, and to discuss the possible mechanism, we analyze the differences of CBF in 29 healthy volunteers before and after alcohol consumption. The results show that CBF changed significantly in brainstem, bilateral hippocampus, left frontal lobe, bilateral thalamus, corpus callosum, anterior cingulate cortex, bilateral cerebellum, bilateral occipital lobe, cuneus and bilateral temporal gyrus. These abnormal activities may have important value in revealing the mechanism of alcohol in the brain.
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