Abstract #5396

Neurochemical Basis of the BOLD Change in Attention Control - a combined task-based fMRI and 1H-MRS

Pui Wai Chiu^1,2, Hui Zhang¹, Issac Ip³, Savio Wai Ho Wong³, Tianyin Liu⁴, Gloria Hoi Yan Wong⁵, Queenie Chan⁶, Kelvin Kai Wing Yau⁷, Leung Wing Chu^8,9, and Henry Ka Fung Mak^1,2,9

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, Hong Kong, ³Department of Special Education and Counselling, The Education University of Hong Kong, Hong Kong, Hong Kong, ⁴Sau Po Centre on Ageing, The University of Hong Kong, Hong Kong, Hong Kong, ⁵Department of Social Work and Administration, The University of Hong Kong, Hong Kong, Hong Kong, ⁶Philips Healthcare, Hong Kong, Hong Kong, Hong Kong, ⁷Department of Management Sciences, City University of Hong Kong, Hong Kong, Hong Kong, ⁸Department of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong, ⁹Alzheimer's Disease Research Network, The University of Hong Kong, Hong Kong, Hong Kong

fMRI can indirectly measure brain activity, but the biochemical underpinnings of the BOLD changes are still unknown. Nevertheless, ¹H-MRS can bridge such gap by measuring Glx [summation of glutamate (Glu) and glutamine (Gln)], where Glu is one of the mediators of neurovascular coupling. In this study, we aim to elucidate the complex relationship between attention control (numerical Stroop) and its associated neurochemical changes by combining the biochemical information from task-based fMRI and¹H-MRS. Our result showed that the anterior cingulate cortex was positively correlated with Glx. This is the first study providing neurochemical explanation of the BOLD change during attention control task.

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