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Abstract #5421

MR Relaxation Properties in MR Coagulation for Vascular Repair

Ming Zhao 1,2, Ouri Cohen2, Erez Nevo3, R.Gilberto Gonzalez2, and Jerome L. Ackerman2

1Department of Physics, University of Massachusetts Lowell, Lowell, MA, United States, 2Martinos Center, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 3Robin Medical, Inc., Baltimore, MD, United States

As part of a project to develop MR-induced RF heating of a coagulable biomaterial for minimally invasive repair of vascular lesions, we investigate the relationship between the heat coagulation behavior and MR relaxation properties of egg white. This protein solution is a good model for the analogous behavior of human serum albumin solution, an optimal (but expensive) biomaterial for MR coagulation. We find that large changes in both T2 and the width of the magnetization transfer spectrum clearly indicate the temperature at which the coagulation process occurs. T2 and MT weighted MR images identify coagulated material in an aneurysm phantom.

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