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Abstract #5466

Magnetization exchange between water and downfield metabolites in human brain at 9.4T

Nicole D Fichtner1,2, Ioannis-Angelos Giapitzakis3, Nikolai Avdievich3, Ralf Mekle4, Daniel Zaldivar3, Anke Henning2,3, and Roland Kreis1

1Depts. Radiology and Clinical Research, University Bern, Bern, Switzerland, 2Institute for Biomedical Engineering, UZH and ETH Zurich, Zurich, Switzerland, 3Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 4Center for Stroke Research Berlin (CSB), Charité Universitätsmedizin Berlin, Berlin, Germany

Ultra-high field strengths provide higher signal to noise ratio and improved separation of metabolites in spectroscopy, allowing for more precise characterization of peaks. In particular, this improved peak resolution may be of benefit for characterization of the downfield (5-10ppm) spectrum, which is not yet well characterized; this experiment aims to improve knowledge of downfield peaks by investigating their exchange rates and T1 values at 9.4T, using inversion transfer experiments and metabolite cycling to allow for non-water suppressed acquisition.

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