Numerical simulations of three-dimensionally localized MRS spectra have been very time-consuming for multi-spin systems because the current state-of-the-art requires computation of a large ensemble of spins pixel-by-pixel in three dimensional space. In this abstract it was found that spatial coordinates of the full set of spin density operators labeled by slice selection gradients can be projected onto one dimension after slice selection as long as the crusher gradients are refocused. Therefore, the conventional three-dimensional simulation can be converted to a one-dimensional problem in cases such as the commonly used PRESS or STEAM. The proposed method was implemented using a computer program written in Java language.
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