Direct Asp observation using PRESS, STEAM etc. in the human brain is strongly complicated by J-evolution and overlapping with other metabolites. In this work we have adjusted MEGA-PRESS for simultaneous Asp and Glu estimation. According to Vespa simulation as well as phantoms and in vivo studies TE=115ms was chosen as the best for Asp (2.65 and 2.80 ppm) and Glu (2.13 ppm) quantification without overlapping. Asp is the main precursor of neuronal marker NAA. NAA have been shown to be reduced in many disorders. Using this method allows accurate investigation of this important metabolic pathway.
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