Abstract #5514

semi-adiabatic SPECIAL-based 1H MRSI at 9.4T: Implementation and preliminary validation in a rat brain

Hyeong-Hun Lee¹ and Hyeonjin Kim^1,2,3

¹Department of Biomedical Sciences, Seoul National University, Seoul, Korea, Republic of, ²Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Suwon, Korea, Republic of

Given the issues of chemical shift displacement error, B₁ inhomogeneity and short T₂ at high field, a semi-adiabatic SPECIAL-based MRSI sequence was implemented at 9.4T, which is equipped with a pair of broad-band hyperbolic secant adiabatic full passage pulses for refocusing, and yet, allows a minimum TE of as short as 4.98 ms. In phantom, the effect of the prolonged minimum TE on the J-evolution of coupled spins is negligible. In a rat brain, preliminary quantitative results are in close agreement with the previous results obtained by using single-voxel MRS.

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