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Abstract #5561

Contrast Deposition Within the Dentate Nucleus After Repetitive Administration: Comparison of Linear versus Macrocyclic Gadolinium Contrast Agents

Eugene Huo1, Bing Tian1, David Saloner1, Michael Hope1, Christopher Hess1, William Dillon1, and Thomas Hope1

1Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

Although gadolinium deposition in nephrogenic systemic fibrosis is limited to patients with abnormal renal function, more recent rat and human studies have demonstrated gadolinium deposition in specific brain structures in subjects without renal failure. We report here one of the largest studies evaluating gadolinium deposition in terms of both number of patients and number of doses, verifying the impact of the structural differences between the two most commonly used classes of agents (linear vs macrocyclic) and demonstrating a previously undescribed plateau in signal intensity ratio increase in patients who have received more than 25 administrations of gadolinium.

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