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Abstract #5575

Impact of Abdominal Magnetic Resonance Imaging on DNA Double Strand-Breaks in Human Blood Lymphocytes

Saravanabavaan Suntharalingam1, Emil Mladenov2, Georg Iliakis2, Michael Forsting1, Oliver Kraff3,4, Harald H. Quick3,4, and Kai Nassenstein1

1Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany, 2Institute of Medical Radiation Biology, University Hospital Essen, Essen, Germany, 3Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Hospital Essen, Essen, Germany, 4High Field and Hybrid MR Imaging, University Hospital Essen, Essen, Germany

Magnetic resonance imaging is considered to be a safe alternative to other imaging techniques that use ionizing radiation, such as computed tomography. Initially driven by X-ray and CT imaging studies, within the recent years different in vitro and in vivo studies analyzed the impact of MR imaging on DNA integrity in human lymphocytes but reported contradictory results. In this study on patients referred to clinical abdominal MRI, γ-H2AX immunofluorescence microscopy was used to determine DNA integrity. No evidence of DNA damage induced by abdominal MRI in a clinical setting was found.

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