Abstract #5601

Phenformin Induces Profound Metabolic Changes in Lung Cancer Cells

Santosh Kumar Bharti¹, Ellen Tully², Edward Gabrielson², and Zaver M Bhujwalla^3,4

¹Radiology, JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD, United States, ²Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, United States

Lung cancer is a leading cause of cancer associated death in United States and worldwide. Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancer cases in the United States. Use of metformin is associated with improved cancer treatment outcomes, reduction in cancer incidence and decreased mortality, and because of a higher potency, phenformin may be a more promising anti-cancer agent. Here, we have used 1H MRS of cell extracts to investigate the effect of phenformin on A549 cells. Significant metabolic changes were observed following phenformin treatment

This abstract and the presentation materials are available to members only; a login is required.

Join Here