Abstract #5610

Effect of hyperbaric oxygenation on human brain phosphate metabolites at 3 Tesla. In vivo 31P MRS study

Andrei Valerievich Manzhurtsev^1,2, Olga Vasyukova³, Victoria Victorovna Sergeeva⁴, Tolibjon Abdullaevich Akhadov², Ilia Andreevich Mel'nikov², Olga Vasil'evna Bozhko², and Natalia Alexandrovna Semenova^1,2,5

¹N.M.Emanuel Institute of Biochemical Physics of RAS, Moscow, Russian Federation, ²Radiology, Research Institute for Childen Emergency Surgery and Traumatology, Moscow, Russian Federation, ³National Research Nuclear University "MEPhI", Moscow, Russian Federation, ⁴Hyperbaric Oxygenation Dept., Research Institute for Childen Emergency Surgery and Traumatology, Moscow, Russian Federation, ⁵N.N. Semenov Institute of Chemical Physics of RAS, Moscow, Russian Federation

This study is aimed to reveal the effects of hyperbaric oxygenation on human brain phosphate metabolites using ³¹P MRS. At first, ³¹P MRS study was conducted, after that the subjects took a session in hyperbaric chamber (1.2 atmosphere, 100% O₂) and then ³¹P MRS study was repeated. The increase of α-ATP peak intensity was revealed after hyperbaric oxygenation, while other peak intensities and pH remained unchanged. This phenomenon is likely to happen because of [NAD(H)] increase, that might confirm the positive effect of hyperbaric oxygenation on human brain metabolism.

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