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Abstract #5614

Dynamic 31P MR spectroscopy of fatigue in triceps surae muscles on post-poliomyelitis patients versus healthy age-matched volunteers at 3T

Xeni Deligianni1,2, Tanja Haas3, Patricia Hafner4, Simone Schmidt4, Vanya Gocheva4, Francesco Santini1,2, Oliver Bieri1,2, and Dirk Fischer4

1Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland, 2Biomedical Engineering, University of Basel, Basel, Switzerland, 3Radiology, Clinic for Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland, 4Pediatric Neurology, Universit├Ąts-Kinderspital beider Basel (UKBB), Basel, Switzerland

This study was focused on comparing the metabolism of triceps surae muscles on postpoliomyelitis patients and age-matched healthy volunteers through dynamic 31P spectra acquisition at 3T magnetic field. It has been suggested previously that in postpolio patients, metabolic changes are secondary to neurogenic pathways, but may influence Pi/PCr ratios. Here, it was shown that baseline PDE/PCr ratios were higher in patients. During exercise, controls performed significantly higher work and the change of Pi/PCr ratios was lower than in patients. Investigation of the correlation of Pi/PCr with the degree of the disease could be a promising clinical direction.

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