Abstract #5653

Microstructural dynamic changes in ischemic stroke in humans measured with diffusion-weighted magnetic resonance spectroscopy at 3 T

Francesca Branzoli^1,2, Bélen Díaz-Fernández ³, Malgorzata Marjanska⁴, Edward Auerbach⁴, Romain Valabrègue^1,2, Itamar Ronen⁵, Stéphane Lehéricy^1,2, and Charlotte Rosso^1,2,3

¹Brain and Spine Institute (ICM), Center for Neuroimaging Research (CENIR), Paris, France, ²UPMC Paris 6, INSERM, U1127; CNRS, UMR 7225, Paris, France, ³Service des Urgences Cérébrovasculaires, Hòpital Pitié-Salpétrière, Paris, France, ⁴Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ⁵C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

Diffusion-weighted ¹H magnetic resonance spectroscopy (DW-MRS) probes the diffusion properties of metabolites, which are differentially compartmentalized in brain tissue and are thus more specific than water molecules to the intra-cellular environment. The aim of this study was to measure water and metabolite diffusion in the human brain in the acute, sub-acute and choronic stage of ischemic stroke, in order to better characterize the microstructural dynamic changes ongoing at different stages of the disease, in both infarcted and periferal regions, by disentangling neuronal, glial and extra-cellular pathological processes.

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