In-vitro cardiovascular simulation permits quantification of hemodynamics that cannot be assessed in-vivo. However, simulation accuracy depends on anatomical and physiological realism of in-vitro models and flow. To determine the effect of model compliance and pulsatile flow, a rigid model of an aorta was compared with a geometrically identical compliant model. Models were perfused with pulsatile flow using a positive displacement pump. Flow dynamic parameters for simulations, obtained using 4D flow MRI, showed that model compliance plays a significant role in hemodynamics during pulsatile flow. Future development of realistic in-vitro simulation, paired with in-vivo validation, will aid in surgical planning.