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Abstract #0013

Alterations of Cardiac 4D Hemodynamics and Blood Energetics in Hypertrophic Cardiomyopathy

Aakash Gupta1, Michael Markl1,2, Bradley Allen1, Lubna Choudhury3, James Carr1,2,3, Robert Bonow3, and Jeremy Collins1

1Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 2Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Chicago, IL, United States, 3Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States

4D flow MRI supports the development of novel energetic biomarkers in hypertrophic cardiomyopathy (HCM) – a disease marked by dynamic left ventricular outflow tract obstruction with mitral regurgitation (MR). We compared kinetic energy and velocity metrics between obstructive and non-obstructive HCM subtypes to determine where in the left heart high kinetic energy and flows were generated. Left atrium showed significantly higher systolic kinetic energy and velocities throughout ventricular systole due to MR. Including these energetic parameters may be useful to detect significant MR that is underestimated by echo, identify patients at higher risk of atrial fibrillation, and inform treatment options.

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