Quantitative multi-parametric MR imaging is an important component of diagnosis and objective staging of diffuse liver disease, reducing the need for biopsy. The goal of the current study was to validate a new simultaneous proton density fat fraction and water T1-mapping approach (PDFF-T1) with low B1+ sensitivity in a short, patient-friendly breath-hold acquisition. It is shown (simulations, phantoms, in-vivo) that a time-varying flip angle excitation scheme leads to improved accuracy of PDFF and that fat-water separation enables water-specific T1 mapping, all in a single patient-friendly breath-hold, with low sensitivity to inhomogeneity in the transmitted radiofrequency (B1+) field.
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