Previous in-vivo MRI studies on training-induced WM microstructural dynamics were mostly based on DTI measurements showing changes in FA. The non-specificity of FA as a WM marker stimulated us to obtain a more specific characterization of WM microstructural changes. Using multi-parametric MR with the ‘Tractometry’ approach we show significant changes in the fornix post a navigation working memory task. Critically, we report here for the first time significant microstructural changes with susceptibility, shown in vast areas of the fornix. Fr, MD, RD and λ1 also show significant changes but in limited areas of the fornix.
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