Studies of white matter tractography typically investigate fibers that make up long association tracts, such as the arcuate fasciculus. As a result, the local structural connections comprising short association (cortico-cortical), U-shaped fibers, or U-fibers, are poorly understood. Previous work suggests these fibers play an important role in communication between adjacent cortical regions. We introduce a flexible, data-driven tool incorporating multimodal MRI techniques to aid differentiation of fiber tracts via clustering techniques, including a filter to identify and extract U-fibers. Using this tool, we present a preliminary investigation of U-fibers between controls (N=20) and patients diagnosed with temporal lobe epilepsy (N=19).
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