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Abstract #0075

Combined Gadoxetic Acid and Gadobenate Dimeglumine Enhanced Liver MRI for Liver Metastasis Detection: A Parameter Optimization Study

Gesine Knobloch1, Timothy Colgan1, Xiaoke Wang1,2, Tilman Schubert1, Diego Hernando3, and Scott Reeder1,2,3,4,5

1Department of Radiology, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, 2Department of Biomedical Engineering, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, 3Department of Medical Physics, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, 4Department of Medicine, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, 5Department of Emergency Medicine, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States

The detection of small perivascular metastatic lesions can be challenging with gadoxetic acid-enhanced liver MRI because both, blood vessels and metastases appear hypointense during the hepatobiliary phase. We sought to demonstrate the feasibility of combined gadoxetic acid (GA)/gadobenate dimeglumine (GD) liver MRI for improved lesion detection and optimize the imaging protocol regarding GA-dosing, imaging time after GD-injection and flip angle. Preliminary results show a homogenously enhanced liver and vasculature (“plain-white-liver”) 1-3min after GD-bolus detection with optimal contrast using flip angles of 25-35°. The combined GA/GD protocol has potential to improve the diagnostic performance of hepatobiliary phase liver MRI.

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