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Abstract #0083

Spatiotemporal development of spinal cord lesions in a primate model of multiple sclerosis

Jennifer A. Lefeuvre1,2, Pascal Sati1, Cecil Chern-Chyi Yen3, Seung Kwon A. Ha1, Wen-Yang Chiang3, Mathieu D. Santin2, Steven Jacobson4, Afonso C. Silva3, Stéphane Lehéricy2, and Daniel D. Reich1

1NINDS, National Institutes of Health, bethesda, MD, United States, 2CENIR, Institut du Cerveau et de la Moelle epinière, Paris, France, 3National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, 4National Institute of Neurological Disorders and Stroke, National Institutes of health, Bethesda, MD, United States

The spatiotemporal development of spinal cord (SC) lesions in multiple sclerosis (MS) is poorly understood, despite the high prevalence of these lesions and their important contribution to patient disability. In this study, we report for the first time the serial imaging of SC lesions in a nonhuman primate model of MS. The results demonstrated substantial clinical and imaging features shared between this animal model and human MS. In particular, we observed focal and subpial demyelinating lesions that appeared at disease onset and proceeded to affect much of the entire cord over the course of several weeks to months.

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