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Abstract #0109

Hollow Manganese-Silicate (HMS) Nanoparticles as a Liver Specific MRI contrast agent

Moon-Sun Jang1, Jin Goo Kim2, Geun Ho Im1, Jung Hee Lee1,3, Won Jae Lee1, and In Su Lee2

1Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, 2National Creative Research Initiative Center for Nanospace-confined Chemical Reactions and Department of Chemistry, Pohang University of Science and Technology (POSTECH), Gyeongbuk, Republic of Korea, 3Departments of Health Science and Technology and Medical Device Management and Research, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, Republic of Korea

In this study, we demonstrate hollow manganese silicate nanoparticle (HMS) as a liver specific magnetic resonance imaging (MRI) contrast agent. HMS releases Mn2+ ions in the acidic physiological condition, which can be utilized for characterizing different tumor types.

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