The pH-value as physiological marker for clinical diagnosis can be measured with special hardware over 31P-MRSI. APT-CEST MRI offers an alternative method for such quantification but is challenging because of magnetization transfer from other tissue compartments.
To evaluate the role of pH for APT-CEST, we investigated 12 patients with first diagnosis of glioblastoma and 11 healthy controls, based on asymmetric analysis of magnetization transfer (MTRasym) and calculated pH maps over 31P-MRSI.
Our results show a high correlation between both parameters and support the hypothesis that an enhancement of MTRasym at 3.5ppm is associated with increased pH.This abstract and the presentation materials are available to members only; a login is required.