Whole-body diffusion with background suppression (DWIBS) has increased sensitivity and specificity for metastatic cancer detection. However, DWIBS using echo-planar readout suffers from geometric distortions due to large B0 inhomogeneities associated with large FOV, used in whole-body MRI. Additionally, DWIBS suffers from low spatial resolution and long scan times due to low signal to noise ratio. In this work, we developed an alternative WB-MRI technique at 3T using fast, high-resolution and high-SNR T2-weighted imaging with simultaneous fat and fluid suppression, called DETECT. Patient studies show that, DETECT is time-efficient, robust, and generates distortion-free images with good lesion conspicuity, compared to DWIBS.