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Abstract #0160

Multi-vendor, multi-site comparison of 1H-MRS PRESS data acquired at 25 research sites

Michal Považan1,2, Mark Mikkelsen1,2, Adam Berrington1,2, Peter B. Barker1,2, Pallab K. Bhattacharyya3,4, Maiken K. Brix5,6, Pieter F. Buur7, Kim M. Cecil8, Kimberly L. Chan1,2,9, David Y.-T. Chen10, Alexander R. Craven11,12, Koen Cuypers13,14, Michael Dacko15, Niall W. Duncan16, Ulrike Dydak17, David A. Edmondson17, Gabriele Ende18, Lars Ersland11,12,19, Fei Gao20, Ian Greenhouse21, Ashley D. Harris22, Naying He23, Stefanie Heba24, Nigel Hoggard25, Tun-Wei Hsu26, Jacobus F. A. Jansen27, Alayar Kangarlu28,29, Thomas Lange15, R. Marc Lebel30, Yan Li23, Chien-Yuan E. Lin31, Jy-Kang Liou26, Jiing-Feng Lirng26, Feng Liu29, Ruoyun Ma17, Celine Maes13, Marta Moreno-Ortega28, Scott O. Murray32, Sean Noah21, Ralph Noeske33, Michael D. Noseworthy34, Georg Oeltzschner1,2, James J. Prisciandaro35, Nicolaas A. J. Puts1,2, Timothy P. L. Roberts36, Markus Sack18, Napapon Sailasuta37,38, Muhammad G. Saleh1,2, Michael-Paul Schallmo32, Nicholas Simard39, Stephan P. Swinnen13,40, Martin Tegenthoff24, Peter Truong37, Guangbin Wang20, Iain D. Wilkinson25, Hans-Jörg Wittsack41, Hongmin Xu23, Fuhua Yan23, Chencheng Zhang42, Vadim Zipunnikov43, Helge J. Zöllner41,44, and Richard A. E. Edden1,2

1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Imaging Institute, Cleveland Clinic Foundation, Cleveland, OH, United States, 4Radiology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, United States, 5Department of Radiology, Haukeland University Hospital, Bergen, Norway, 6Department of Clinical Medicine, University of Bergen, Bergen, Norway, 7Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 8Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 9Department of Biomedical Engineering, The Johns Hopkins University, School of Medicine, Baltimore, MD, United States, 10Department of Radiology, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan, 11Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway, 12NORMENT – Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway, 13Department of Kinesiology, KU Leuven, Leuven, Belgium, 14REVAL Rehabilitation Research Center, Hasselt University, Diepenbeek, Belgium, 15Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany, 16Brain and Consciousness Research Centre, Taipei Medical University, Taipei, Taiwan, 17School of Health Sciences, Purdue University, West Lafayette, IN, United States, 18Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany, 19Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway, 20Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, 21Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States, 22Department of Radiology, University of Calgary, Calgary, AB, Canada, 23Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China, 24Department of Neurology, BG University Hospital Bergmannsheil, Bochum, Germany, 25Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, 26Department of Radiology, Taipei Veterans General Hospital, National Yang-Ming University, School of Medicine, Taipei, Taiwan, 27Department of Radiology, Maastricht University Medical Center, Maastricht, Netherlands, 28Department of Psychiatry, Columbia University, New York, NY, United States, 29New York State Psychiatric Institute, New York, NY, United States, 30GE Healthcare, Calgary, AB, Canada, 31GE Healthcare, Taipei, Taiwan, 32Department of Psychology, University of Washington, Seattle, WA, United States, 33GE Healthcare, Berlin, Germany, 34Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada, 35Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States, 36Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States, 37Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada, 38Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 39School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, 40Leuven Research Institute for Neuroscience & Disease (LIND), KU Leuven, Leuven, Belgium, 41Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany, 42Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 43Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, 44Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany

In vivo 1H MR spectroscopy (MRS) provides valuable information regarding various brain disorders. In order to enable further clinical acceptance of MRS, this technique needs to be robust across multiple sites and MR vendors. Therefore, we analyzed data from 288 healthy subjects from 25 research sites across the three major vendors and examined vendor-, site- and participant-related effects on metabolites detected by PRESS 1H-MRS at 3T. Within-site and inter-site coefficients of variation were between 2-16%. Significant effects of vendor were found for Ins/tCr and Glx/tCr. Effect of sites contributed ~30% to total variance of all quantified metabolites.

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