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Abstract #0206

Quantitative MRI in early intervertebral disc degeneration: T1rho correlates better than T2 and ADC with biomechanics and matrix content

Cornelis Paul1, Theodoor Smit1, Magda de Graaf2, Roderick Holewijn2, Arno Bischop2, Peter van de Ven3, Margriet Mullender4, Marco Helder5, and Gustav Strijkers6

1Orthopedic Surgery, Academic Medical Center, Amsterdam, Netherlands, 2Orthopedic Surgery, VU University Medical Center, Amsterdam, Netherlands, 3Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands, 4Plastic, Reconstructive and Hand Surgery, VU University Medical Center, Amsterdam, Netherlands, 5Oral and Maxillofacial Surgery, VU University Medical Center, Amsterdam, Netherlands, 6Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands

We correlated quantitative T2, T1rho and Apparent Diffusion Coefficient (ADC) values to disc mechanical behavior and gold standard early DDD markers in a graded degenerated lumbar IVD caprine model to assess their potential for early DDD detection. T1rho nucleus values correlate better than T2 and ADC with biomechanical, histological, and GAG changes.

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