The main challenge in high-resolution EPI is the significant B0-distortion and T2*-blurring artifacts. PSF-encoded EPI has been proposed to achieve distortion- and blurring- free imaging at a cost of extremely long acquisition time, not practical for most applications. In this work, we introduce the “tilted-CAIPI” method, which can provide >20x acceleration for PSF-EPI by utilizing the concept of B0-inhomogeneity encoding and optimized sampling. With the proposed method, PSF-encoded EPI at a 1mm resolution range can be obtained using just 4-8 EPI-shots. PSF-EPI with tilted-CAIPI was demonstrated for efficient acquisition of distortion- and blurring- free T2-weighted, T2*-weighted, and diffusion-weighted images.