Meeting Banner
Abstract #0234

Abnormal Perfusion and Perfusion fluctuation in Bipolar Disorder measured by ASL

Weiying Dai1, Mingzhao Chen1, Li Zhao2, Nicolas Bolo3, David C. Alsop2, and Keshavan Matcheri3

1State University of New York at Binghamton, BINGHAMTON, NY, United States, 2Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, 3Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States

We aim to investigate whether dynamic perfusion image time series instead of static perfusion image can offer extra insight to bipolar disorder (BD). Average perfusion and perfusion fluctuation maps were compared between patients with BD and controls using customized Statistical non-Parametric Mapping (SnPM). Perfusion decrease in the posterior lateral regions of the default mode network and increase of perfusion fluctuations in the parahippocampus and amygdala regions were observed. The abnormal perfusion fluctuations may be supported by perturbed functional connectivity at the same regions. These results indicate that dynamic perfusion image series may serve as potential novel neuroimaging biomarkers for BD.

This abstract and the presentation materials are available to members only; a login is required.

Join Here