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Abstract #0236

Deletion of CRTC1 is associated with strong neuroenergetic dysfunctions in a mouse model of mood disorders.

Antoine Cherix1, Guillaume Donati1, Blanca Lizarbe1, Hongxia Lei2, Carole Poitry-Yamate2, Jean-René Cardinaux3, and Rolf Gruetter1,4,5

1Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Animal Imaging and Technology Core (AIT), Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne., Lausanne, Switzerland, 3Center for Psychiatric Neuroscience (CNP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, 4Department of Radiology, University of Geneva, Geneva, Switzerland, 5Department of Radiology, University of Lausanne, Lausanne, Switzerland

This project pursues a previous study presented at ISMRM1 which established an age- and brain region dependent neurochemical metabolic profile in a Crtc1-/- based mouse model of mood disorders. Here, we show that a decline in cerrebral lactate levels is a consistent and reliable endophenotype2 of Crtc1 deletion, and an indicator of neuroenergetic dysfunction in the dorsal hippocampus. The decline in brain lactate levels appears to arise from a measured reduction of glucose entering the brain.

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