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Abstract #0333

Subregional bone marrow adipose tissue composition in the proximal femur: Comparison of 3T Chemical Shift Encoded-MRI and Magnetic Resonance Spectroscopy

Dimitri MARTEL1, Benjamin LEPORQ2, Mary BRUNO1, Stephen HONIG3, Amit SAXENA4, H.Michael BELMONT4, Gabrielle TURYAN1, Ravinder R. REGATTE1, and Gregory CHANG1

1Radiology, NYU Langone Health, New York, NY, United States, 2Université de Lyon; CREATIS CNRS UMR 5220, Inserm U1206, INSA-Lyon, UCBL Lyon 1, Villeurbanne, France, 3Osteoporosis Center, Hospital for Joint Diseases, NYU Langone Health, New York, NY, United States, 4Department of Rheumatology, NYU Langone Health, New York, NY, United States

Studies of bone marrow adipose tissue (bMAT) composition in osteoporosis has revealed increased [a1] in fat content and decreased unsaturated fatty acid in the proximal femur in osteoporosis (OP) patients compared to controls. Advancements in MR image-based methods for fat assessment have allowed quantification of fat content though chemical-shift encoded MRI (CSE-MRI). CSE-MRI methods have not been compared to MRS for bMAT composition assessment. The aim of this study was to quantify, within subregions of the proximal femur, bone marrow PDFF as well as saturated and unsaturated fat using both CSE-MRI and MRS.

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