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Abstract #0371

ASL imaging and 31P/1H-MRS during prolonged breath-hold among experienced freedivers: Insights into cerebrovascular and metabolic responses

Vera Catharina Keil1, Henri Jan Mutsaerts2,3,4, Lars Eichhorn5, Frank Träber1, Wolfgang Block1, Burkhard Mädler6, Kim van de Ven7, Jeroen C. Siero2,8, Bradley J. MacIntosh3, Jan Petr9, Hans H. Schild1, and Elke Hattingen1

1Department of Radiology, University Hospital Bonn, Bonn, Germany, 2Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 3Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada, 4Radiology Department, Amsterdam Medical Center, Amsterdam, Netherlands, 5Department of Anesthesiology, University Hospital Bonn, Bonn, Germany, 6Philips Healthcare, Bonn, Germany, 7Philips Healthcare, Best, Netherlands, 8Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 9Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

This pCASL and 31P/1H-MRS study explored the cerebrovascular reactivity (CVR) and its efficacy on brain metabolic stability during a five-minute breath-hold in fifteen experienced freedivers. Cerebral blood flow (CBF) increase occurred later than the decrease of the recently discovered arterial transit time correlate, spatial CoV. The latter may thus be an early CVR biomarker. CBF varied between vessel territories, gray and white matter and usually lowered with more experience. MRS showed near stable physiological cerebral pCr, ATP and pH concentrations despite peripheral lactate acidosis. In conclusion, this trial revealed that CVR sufficiently compensates the metabolic challenge of a five minute breath-hold.

In conclusion, this trial revealed that cerebral perfusion increase sufficiently compensates the metabolic challenge of a five-minute breath-hold.

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