Meeting Banner
Abstract #0404

Multimodality cellular and molecular imaging of the impact of a primary tumor on metastatic growth in a syngeneic mouse model of breast cancer brain metastasis

Katie Parkins1, Veronica Dubois1, Amanda Hamilton2, Ashley Makela1, John Ronald1, and Paula Foster1

1Medical Biophysics, Western University, London, ON, Canada, 2Western University, London, ON, Canada

The mechanisms that influence metastatic growth rates are poorly understood. One mechanism of interest known as concomitant tumor resistance (CTR) can be defined as the inhibition of metastatic growth by existing tumor mass. Conversely, the presence of a primary tumor has also been shown to increase metastatic outgrowth, termed concomitant tumor enhancement (CTE). The goal of this research was to use conventional and cellular MRI , and bioluminescence imaging to study the impact of a primary tumor on the development of breast cancer brain metastases in a syngeneic mouse model.

This abstract and the presentation materials are available to members only; a login is required.

Join Here