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Abstract #0408

NOE-mediated CEST Imaging of Glioma at 7 Tesla Aids Early Response Evaluation of Patients Undergoing Radio-Chemotherapy

Jan-Eric Meissner1, Sebastian Regnery2, Andreas Korzowski1, Steffen Goerke1, J├╝rgen Debus2, Heinz-Peter Schlemmer3, Mark E. Ladd1, Peter Bachert1, Sebastian Adeberg2, and Daniel Paech3

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Radiation Oncology, Medical Faculty, University of Heidelberg, Heidelberg, Germany, 3Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Reliable biomarkers for an early assessment of treatment response are urgently needed. In this study, we investigated the rNOE-mediated CEST signals in patients undergoing radio- and chemotherapy at three different time points including pre and post treatment. The results were compared to the standard clinical determination of responders and non-responders (RANO criteria) and the relaxation compensated CEST contrast NOEAREX showed a statistically significant difference between the two groups directly after therapy. Hence, NOEAREX might potentially help determining early tumor response to therapy.

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