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Abstract #0461

Quantitative Assessment of Disc Biochemical Composition and Vertebral Body Fat in Patients with Low Back Pain

Roland Krug1, Misung Han1, Aaron Fields2, Gabby Joseph1, Justin Cheung1, Maya Mundada1, Alice Rochette2, Jeannie Bailey2, Alexander Ballatori2, Thomas Link1, Zachary McCormick2, Conor O'Neill2, and Jeffrey Lotz2

1Radiology, UCSF, San Francisco, CA, United States, 2Orthopedic Surgery, UCSF, San Francisco, CA, United States

We present a cross sectional study of 53 subjects with chronic lower back pain (n=39) and healthy controls (n=14). We have assessed disc biochemical composition (T1rho and T2 mapping) and vertebral bone marrow fat (6-point chemical-shift based imaging) as well as Pfirrmann grading. We have found significant associations between mean and standard-deviation of T1rho and T2 with vertebral bone marrow fat content in the adjacent vertebral body. We have also found strong associations of T1rho and T2 with clinical Pfirrmann grading.

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