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Abstract #0469

Longitudinal multi-component HARDI atlas of neonatal white matter

Maximilian Pietsch1,2, Daan Christiaens1,2, Jana Hutter1,2, Lucilio Cordero-Grande1,2, Anthony N Price1,2, Emer Hughes1, A. David Edwards1, Joseph V. Hajnal1,2, Serena J Counsell1, and J-Donald Tournier1,2

1Centre for the Developing Brain, School of Bioengineering and Imaging Sciences, King's College London, London, United Kingdom, 2Department of Biomedical Engineering, School of Bioengineering and Imaging Sciences, King's College London, London, United Kingdom

We describe a method for creating a longitudinal atlas of developing white matter (WM) of neonates using the multi-shell multi-tissue constrained spherical deconvolution technique and multi-contrast registration on high-quality high angular resolution diffusion imaging (HARDI) data. We present an atlas that consists of one isotropic and two orientationally-resolved components. The atlas reveals fibre-specific patterns of WM maturation that are consistent with regional differences in maturation previously described in histological studies of the developing brain.

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