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Abstract #0497

Quantitative assessment of exercise-stimulated muscle perfusion: a comparison between DCE and DSC imaging

Jeff L Zhang1, Christopher C Conlin1, Stephen Decker2, Gwenael Layec2, Jiawei Dong1, Xiaowan Li1, Nan Hu3, Christopher Hanrahan1, Lillian Khor4, Michelle Mueller5, and Vivian S Lee1

1Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, 2Division of Geriatrics, University of Utah, Salt Lake City, UT, United States, 3Epidemiology, University of Utah, Salt Lake City, UT, United States, 4Cardiovascular Medicine, University of Utah, Salt Lake City, UT, United States, 5Vascular Surgery, University of Utah, Salt Lake City, UT, United States

For one group of healthy subjects, we measured exercise-stimulated perfusion in calf muscles using both DCE and DSC MRI, and found that the muscle perfusion estimates by the two methods were comparable, but the vascular-fraction estimates were not. Without confounding contribution from extravascular signals, DSC data has the potential of characterizing tissue vasculature more precisely. Acquisition of both DCE and DSC data in one exam can be achieved with either two injections of low contrast dose or acquisition techniques of interleaved T1 and T2* imaging.

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