Anisotropy effects were proven to strongly affect T2* and DSC-measurements, however influences on the relative Oxygen Extraction Fraction (rOEF) by multi-parametric quantitative BOLD (mq-BOLD) have not been investigated yet. Therefore, we present a methodolocigal study within healthy elderly. The major aim was to evaluate anisotropy effects on rOEF and all mq-BOLD related parameters at the same time. We found strong orientation dependencies of T2*, T2, R2' and rCBV on the main-nerve-fiber orientation towards B0 with variations up to 26.6%. However, our results show rather low angle dependency of rOEF with 13.6% as R2’ and rCBV effects show partially counteracting influences.