Abstract #0514

Liver R2* as a Biomarker of Liver Iron Concentration: Interim Results from a Multi-Center, Multi-Vendor Reproducibility Study at 1.5T and 3T

Diego Hernando^1,2, Ruiyang Zhao^1,2, Valentina Taviani³, Mounes Aliyari Ghasabeh⁴, Li Pan⁵, Qing Yuan⁶, Stefan Ruschke⁷, Dimitrios C. Karampinos⁷, Xiaodong Zhong⁸, Ryan J. Mattison⁹, Ihab R. Kamel⁴, Ivan Pedrosa⁶, Shreyas Vasanawala¹⁰, Takeshi Yokoo^6,11, and Scott B. Reeder^1,2,9,12,13

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³Global MR Applications & Workflow, GE Healthcare, Menlo Park, CA, United States, ⁴Radiology, The Johns Hopkins University, Baltimore, MD, United States, ⁵Siemens Healthineers, Baltimore, MD, United States, ⁶Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁷Radiology, Technical University of Munich, Munich, Germany, ⁸Siemens Healthineers, Los Angeles, CA, United States, ⁹Medicine, University of Wisconsin-Madison, Madison, WI, United States, ¹⁰Radiology, Stanford University, Stanford, CA, United States, ¹¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ¹²Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ¹³Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

R2* is a promising biomarker of liver iron concentration (LIC), with application in the assessment of iron overload. Previous works have demonstrated the high correlation of liver R2* with biopsy-determined LIC. Although R2* measurements may be affected by multiple confounding factors, including the presence of fat and noise bias, confounder-corrected R2* mapping has been shown to be highly insensitive to the presence of these confounding factors. However, the multi-center reproducibility of confounder-corrected R2* for liver iron quantification remains unknown. This abstract demonstrates excellent reproducibility of R2* for liver iron quantification in a multi-center, multi-vendor study at both 1.5T and 3T.

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