Abstract #0533

On the Sensitivity of Bone Marrow Magnetic Susceptibility and R2* on Trabecular Bone Microstructure

Maximilian N. Diefenbach¹, Anh Van², Jakob Meineke³, Jan S. Kirschke⁴, Benedikt Schwaiger¹, Thomas Baum⁴, Alexandra Gersing¹, and Dimitrios C. Karampinos¹

¹Diagnostic and Interventional Radiology, Technical Univeristy of Munich, Munich, Germany, ²Institute of Medical Engineering, Technical University of Munich, Munich, Germany, ³Philips Research Laboratory, Hamburg, Germany, ⁴Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany

In numerical simulations and initial in vivo results of multi-parametric mapping in the calcaneus, the feasibility of measuring trabecular bone microstructure is explored. The combination of R₂^* for measuring intra-voxel dephasing and quantitative magnetic susceptibilty to detect trabecular bone density is investigated and indicates feasibility to differentiate trabecular bone networks with isotropic and anisotropic microstructure.

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