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Abstract #0547

In Vivo Conductivity Imaging of Tissue Response after Radiation Therapy

In Ok Ko1, Bup Kyung Choi2, Nitish Katoch2, Ji Ae Park1, Jin Woong Kim3, Hyung Joong Kim2, Oh In Kwon4, and Eung Je Woo2

1Division of RI Convergence Research, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea, 2Biomedical Engineering, Kyung Hee University, Seoul, Republic of Korea, 3Radiology, Chonnam National University Medical School, Gwangju, Republic of Korea, 4Konkuk University, Seoul, Republic of Korea

Radiation therapy (RT) has been widely used as a powerful treatment to remove cancerous tissues because of its ability to control cell growth. Ionizing radiation works by damaging the DNA of cancerous tissue leading to cellular death. Medical imaging has limitations on credibility for evaluation of tissue response and prediction of therapeutic effect due to lacks of contrast information on gradual and minute tissue changes after RT. Conductivity mapping after RT may provide direct and high sensitive information on tissue response because its contrast mechanism originated from the concentration and mobility of ions in the extra- and intracellular environment.

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