LGE-CMR derived texture features reflect poor prognosis in hypertrophic cardiomyopathy patients with systolic dysfunction: preliminary results

In this study, we evaluated the prognostic value of texture features based on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) images in hypertrophic cardiomyopathy (HCM) patients with systolic dysfunction. 1.5 T CMR cine and LGE images were performed on 67 HCM patients with systolic dysfunction. Texture features were extracted from LGE images. Cox proportional hazard analysis and Kaplan-Meier analysis were used to determine the association of texture features with event free survival. The result showed that increased LGE heterogeneity (higher X0_GLRLM_energy, higher X1_H_uniformity, lower X0_H_skewness and lower X0_GLCM_cluster_tendency) was associated with adverse events in HCM patients with systolic dysfunction.