Abstract #0579

7T MRI allows detection of disturbed cortical layers in medial temporal lobe in patients with Alzheimer’s disease

Boyd Kenkhuis^1,2, Laura Jonkman³, Marjolein Bulk^1,2,4, Mathijs Buijs¹, Jeroen J. Geurts³, Wilma D.J. van de Berg³, and Louise van der Weerd^1,2

¹Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Human Genetics, Leiden University Medical Center, Leiden, Netherlands, ³Anatomy and Neurosciences, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, Netherlands, ⁴Percuros BV, Leiden, Netherlands

Using 7T T2*-w imaging, we scanned post-mortem hemispheres of aged controls and patients with Alzheimer’s disease (AD) to assess the potential of MRI for anatomical cortical parcellation of the medial temporal lobe based on myelo- and cytoarchitectural contrast. Segmentation was possible in both controls and AD scans and distortions in cortical lamination of AD patients could be observed in specific regions of the medial temporal lobe. Observed contrast correlated highly with myelination patterns on histology. 7T MRI may therefore detect pathogenic cortical laminar distortions and provide new information on involved neuroanatomical structures and layers in AD.

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