Short-range functional connections at birth predict neurodevelopmental outcome at 2 years of age
Minhui Ouyang1, Qinmu Peng1,2, Michelle Slinger1, and Hao Huang1,2
1Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
Short-range functional connectivity (FC) is the major contributor to overall significant FC increases around birth. With critical role of short-range FC in neonate brain maturation, we hypothesized that short-range FC at birth predicts the neurodevelopmental outcome at 2 years of age. We measured short-range FC with neonatal resting-state fMRI and used support vector regression (SVR) to predict cognitive scores at 2 years of age. A highly predictive model was achieved with inhomogeneous feature contribution pattern across cortical areas. Significant correlation was found between short-range FC strength in widespread brain regions at birth and cognitive scores at 2 years of age.
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