Animal models of stroke are essential for developing therapies. Rodent models of stroke are widely used but they lack clinical relevance. Endovascular models in large animals are most desired, but till now they were available in expensive and hard-to-access dogs and primates. Swine is preferred model but till now stroke modeling was through surgical craniotomy, a highly invasive procedure inflicting unrelated morbidity. Endovascular modeling was not possible due to vascular rete preventing catheter access to cerebral vessels. We circumvented this obstacle by intra-arterially injecting SPIO-labeled pro-coagulant thrombin under real-time MRI, which was instrumental to fine-tune injection to occlude cerebral arteries.