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Abstract #0622

Creatine Kinase Rate Constant in the Human Heart at 7T: A Novel Superfast Magnetization Saturation Transfer Method

Adil Bashir1, Jianyi Zhang2, Nouha Salibi3, Ronald Beyers4, and Thomas Denney1

1Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, 2Department of Biomedical Engineering, University of Alabama Birmingham, Birmingham, AL, United States, 3Siemens Healthineers and AUMRI Center, Auburn, AL, United States, 4Auburn University, Auburn, AL, United States

Changes in Creatine Kinase (CK) system are observed in heart failure and measurement of CK reaction rate constant (kf) can be useful to monitor pathology. 7T MR scanner offers improved signal to noise and spectral resolution and has potential for robust measurements. In this study we demonstrate novel superfast saturation transfer method (T1nom – method) to measure ATP production rate via CK forward reaction in human hearts at 7T. Spatial localization was achieved by GOIA-1D-ISIS/2D-CSI approach. Our measured kf values were consistent with literature.

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