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Abstract #0670

Spinal Cord MRS Biomarkers of Clinical Impairment in Chronic Spinal Cord Injury

Patrik O. Wyss1,2,3, Eveline Huber4, Patrick Freund4,5,6,7, and Anke Henning1,3,8

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Department of Radiology, Swiss Paraplegic Centre, Nottwil, Switzerland, 3Max-Planck-Institute for Biological Cybernetics, Tuebingen, Germany, 4Spinal Cord Injury Center, University Hospital Balgrist, University of Zurich, Zurich, Switzerland, 5Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, United Kingdom, 6Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom, 7Department of Neurophysics, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 8Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany

Remote neurodegenerative changes above the level of injury are present following traumatic spinal cord injury (SCI), resulting in atrophy of the cervical cord of up to 30%. This study investigates the underlying biochemical changes at the cellular and molecular level which may subtend the development of atrophy using latest magnetic resonance spectroscopy in the spinal cord in healthy controls and SCI patients. Furthermore, we screen for potential MRS biomarkers investigating the association of biochemical changes and clinical outcome.

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