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Abstract #0683

Comprenhensive analysis of Hemodynamics parameters in patients with bicuspid aortic valve using 4D flow data and a finite element method.

Julio Sotelo1,2, Lydia Dux-Santoy3, Andrea Guala3, Aroa Ruiz-Muñoz3, Arturo Evangelista3, Joaquín Mura1, Daniel E Hurtado4,5, José Rodríguez-Palomares3, and Sergio Uribe1,4,6

1Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, 2Department of Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 3Department of Cardiology, Hospital Universitari Vall d´Hebron, Vall d´Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain, 4Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile, 5Department of Structural and Geotechnical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 6Department of Radiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile

Bicuspid aortic valve (BAV) is the most common congenital cardiac defect. Current criteria to support surgical decision in BAV patients has been recently questioned, which motivates the development of better biomarkers to assess the disease stage of development. In this work, we extensively analyze several hemodynamics parameters in volunteers and BAV patients from 4D flow MRI using a finite-element-based quantification framework. We found that the backward velocity fraction, the circumferential WSS, and turbulence parameters, can be used together with the diameters of the vessel as a new risk marker, as it can strongly discriminate subjects from BAV patients.

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