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Abstract #0714

Added value of magnetic resonance spectroscopic imaging to multiparametric MRI for detection of prostate cancer using PIRADS version 2

Virendra Kumar1, Vivek Lanka2, Sanjay Sharma2, Rishi Nayyar3, and Chandan J Das2

1Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, 2Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India, 3Department of Urology, All India Institute of Medical Sciences, New Delhi, India

We report increase in sensitivity, specificity and accuracy of PIRADSv2 by addition of MRSI to mpMRI protocol for detection of cancer of prostate (CaP). 26 patients having a biopsy-proven CaP, were investigated at 3.0T using mpMRI including MRSI, followed by radical prostatectomy within 1 month. PIRADSv2 score for mpMRI, PIRADSv1 score for MRSI and Gleason grade group from radical prostatectomy specimens were determined. ROC curve analysis was used to determine the accuracy for cut-offs. A combination of MRSI PIRADSv1 cut-off ≥4 and PIRADSv2 cut-off ≥3 showed the best accuracy (96.2%) for CaP detection. When MRSI was added to PIRADSv2 scoring we found an improvement from 71.4% sensitivity and 91.9% specificity of PIRADSv2 to 91.8% sensitivity and 98% specificity for detecting CaP.

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