Abstract #0732

Lower oxygenation in the peripheral subarachnoid space reflects decreased cerebral blood flow in dementia-related brain structures

Lisa A. van der Kleij¹, Ilse M.J. Kant², Geert Jan Biessels², Jeroen Hendrikse², Esben T. Petersen³, and Jill B. De Vis⁴

¹Radiology, UMC Utrecht, Utrecht, Netherlands, ²UMC Utrecht, Utrecht, Netherlands, ³2Danish Research Center for Magnetic Resonance, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, ⁴Department of Radiology, MR Research, John Hopkins Medical Center, Baltimore, MD, United States

We evaluated the relationship between cerebral blood flow (CBF) and T₂ of peripheral CSF. The rationale behind this hypothesized association is the presumed dependency of T₂ on oxygenation. The T₂ of CSF was related to CBF and cognition in a group with cognitive decline. In contrast, no relationship was found between the T₂ and CBF in a healthy aging cohort suggesting no relation between the T₂ of CSF and oxygenation. Further investigation regarding the relation between T₂ of CSF and cognition in the healthy aging cohort are ongoing and could shed light on the value of T₂ as a biomarker.

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