Abstract #0756

The intracellular component of VERDICT (Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumors) MRI distinguishes Gleason 4 pattern better than Apparent Diffusion Coefficient

Mrishta Brizmohun Appayya¹, Edward W Johnston¹, Arash Latifoltojar¹, James O’Callaghan¹, Elisenda Bonnet-Carne², Hayley Pye³, Dominic Patel³, Susan Heavey³, Alistair Grey⁴, Sebastien Ourselin³, David Hawkes³, Caroline Moore⁴, Hayley Whitaker³, Alexander Freeman⁴, David Atkinson³, Daniel Alexander³, Eleftheria Panagiotaki³, and Shonit Punwani²

¹Centre of Medical Imaging, UCL, London, United Kingdom, ²Centre for Medical Imaging, UCL, London, United Kingdom, ³UCL, London, United Kingdom, ⁴UCLH, London, United Kingdom

VERDICT (Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumours) MRI combines a diffusion-weighted MRI acquisition with a three-compartment mathematical model that describes signal from i) intracellular water (fIC), ii) water in extracellular-extravascular space (fEES) and iii) water in the microvasculature (fvasc). In contrast to VERDICT, clinical ADC is derived from a mono-exponential model. Upon comparison between VERDICT parameters and clinical ADC, we showed that fIC was better able to discriminate between Gleason ≥3+4 histology pattern and Gleason ≤3+3/benign histology. We also showed that image quality of VERDICT-MRI maps and clinical ADC was comparable.

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